Antidotes en toxicologie d'urgence (3rd ed.). Total volume (step 1) Minus drug volume (step 2)īailey, B., Blais, R., Gaudreault, P., Gosselin, S., & Laliberte, M. (2009). Total Volume (step 1) minus Drug Volume (step 2)Ĭalculate dose and then determine total volume (IV + Drug) to be infusedĭetermine volume of fomepizole 1000 mg/mL needed See table below.Ĭalculate dose and then determine total volume (IV + Drug) to be infusedĭetermine volume of drug to be drawn up from 1000 mg/mL vialĭetermine volume of IV diluent that drug is to be added to Intermittent IV Infusion: Dilute the 1000 mg/mL fomepizole to a final concentration of 25 mg/mL solution and administer over 30 minutes.
In case of eye or skin exposure, flush immediately with copious amounts of water. When preparing fomepizole, avoid ocular, dermal or inhalational exposure.Fomepizole should NOT be administered undiluted or direct.Immediately administer 100% of the next dose, and then follow the normal dosing schedule. Immediately administer 50% of the next scheduled dose, and then follow the normal dosing schedule. Greater than or equal to 1 hour but less than 3 hours Give the next dose 12 hours after the last dose administered, and then follow the normal dosing schedule. Maintenance Doses (During hemodialysis): Same as above but dosing frequency increases to q4h.Continue until criteria for discontinuation are met: normal acid-base status, ethylene glycol level less than 3 mmol/L or methanol level less than 6 mmol/L. Additional doses require an increase to 15 mg/kg IV every 12 hours. Maintenance Doses (No hemodialysis): 12 hours after the initial dose, administer 10 mg/kg IV over 30 minutes every 12 hours for 4 doses if needed.Initial Dose: 15 mg/kg IV over 30 minutes.Use in pediatrics is based on case reports, but no significant adverse events have been reported. Adjunctive treatment for massive acetaminophen overdoses requires consultation with the poison centre.Exposure to other substances metabolized by alcohol dehydrogenase (diethylene glycol, glycol ethers).Suspected or confirmed ethylene glycol or methanol poisoning.Antizol®, 4-methylpyrazole, 4-MP Indications
0 kommentar(er)
